Unraveling transcriptional flow from single cell transcriptomic data...

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Louis Faure

PhD candidate

Medical University of Vienna

About me

My PhD aims to to expand our views on the evolution of neural crest properties. More precisely by unravelling the cell fate decisions of neural crests cells during mouse development and by exploring the heterogeneity of glial cells during development and adulthood in mouse.

My current work is mainly based on the usage of bioinformatic tools such as single-cell transcriptomics data analysis, clustering, pseudotime ordering, combined with biological experiments for validation.

Interests

  • Computational Biology
  • Developmental Biology
  • Evolution
  • Exo-biology

Education

  • PhD candidate in Neuroscience, 2018

    Medical University of Vienna

  • Diploma Institute for Technology Innovation, 2017

    PSL University, Paris

  • Msc in Interdisciplinary Approaches in Life Science, 2016

    Center for Research and Interdisciplinarity, Paris

  • BSc in Life Science, 2013

    Center for Research and Interdisciplinarity, Paris

Skills

python

Python

R

R

Tux

Linux

server

Server managment

gpu3

GPU data analysis

Fiji

ImageJ

insitu

FISH techniques

Cloning

Cloning

ableton

Music production

Recent Publications

Schwann cell precursors represent a neural crest-like state with biased multipotency

The EMBO Journal, (2022)

Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification

Nature Communications, (2022)

Developmental heterogeneity of embryonic neuroendocrine chromaffin cells and their maturation dynamics

bioRxiv, (2022)

Serotonin limits generation of chromaffin cells during adrenal organ development

Nature Communications, (2022)

Experience

 
 
 
 
 
EMBL-EBI: NEUcrest Big Data course
Lecturer
EMBL-EBI: NEUcrest Big Data course
April 2021 – April 2021 Online
Presentation about methods related to trajectory inference analysis.
 
 
 
 
 
INSERM U900 Bioinformatics and computational biology of cancer unit
Intern
INSERM U900 Bioinformatics and computational biology of cancer unit
January 2018 – June 2018 Curie Institute, Paris
Gene Regulation Network inference using pseudotime ordering of scRNAseq data.
 
 
 
 
 
Institute for Theoretical Biology
Intern
Institute for Theoretical Biology
April 2017 – July 2017 Humboldt University, Berlin
Mathematical modeling of microbial metabolism & cyanobacterial phototrophic growth. Kinetic modeling and flux balance analysis.
 
 
 
 
 
Inserm u1001 Research Lab
Intern
Inserm u1001 Research Lab
January 2017 – April 2017 Descartes University, Paris
Heterogeneity of the spontaneous DNA replication errors in single isogenic E.coli cells.
 
 
 
 
 
Laboratory of Biochemistery
Intern
Laboratory of Biochemistery
September 2016 – December 2016 ESPCI, Paris
Abzymes Project: Quantitative selection and evolution at by high throughput screening of antibodies libraries for DNAse reaction, using microfluidics.
 
 
 
 
 
Microbial Morphogenesis and Growth Lab
Intern
Microbial Morphogenesis and Growth Lab
January 2016 – July 2016 Pasteur Institute, Paris
Single-cell study, tracking of the starting of chromosomal segregation over several generations in E. coli, using fluorescence microscopy and quantitative image analysis.
 
 
 
 
 
Labsprint at Petnica Science Center
Teaching Assistant
Labsprint at Petnica Science Center
August 2016 – August 2016 Petnica, Serbia
Worked as a teaching assistant for 2nd year students from Undergraduate program “Frontiers in Life Science”. Helping the lecturer for the setup of the courses, preparing lab supplies, Giving advices to the students for their projects.
 
 
 
 
 
Laboratory of Molecular and Cellular Biology of Eukaryotes
Intern
Laboratory of Molecular and Cellular Biology of Eukaryotes
January 2015 – June 2015 Curie Institute, Paris
Study of regulations of mitochondrial fusion/fission mechanisms in S. cerevisiae. Gene tagging/deletion; Glycerol growth analysis; Microscopy with GFP-tagged strains; Cell transformation.

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